Drug enforcement officers in the US say they have arrested more than 2,200 people in an investigation targeting Mexican trafficking rings.
The joint operation lasted almost two years and culminated on Wednesday with more than 400 arrests across 16 states.
Officers also seized considerable amounts of methamphetamine, marijuana and heroin.
US Attorney General Eric Holder said Project Deliverance had been a significant blow to Mexican cartels.
He said the arrests and seizures would disrupt their operations but also warned that it was only one battle in an ongoing war.
The investigation focused on the infrastructure used to distribute illegal drugs across the US and smuggle guns and cash back to Mexico.
During the 22 months the operation lasted, officers seized more than $150m (£103m), 2.2 tonnes of cocaine, half a tonne of methamphetamine and 62 tonnes of marijuana.
Mr Holder said it had been the most extensive and most successful law enforcement effort to date targeting Mexican drug cartels.
