QINGDAO - A group of Chinese researchers are cultivating human cells to make artificial corneas in a laboratory, bringing hope to some 5 million victims of corneal blindness in China.
The research team from the Ocean University of China (OUC) was expected to produce a complete cornea and begin clinical trials in three to five years, said Fan Tingjun, deputy dean of the College of Marine Life Science at the OUC.
An artificial cornea, each expected to cost 10,000 to 20,000 yuan (US$1,475 to US$2,950), would provide an alternative for those patients anxiously awaiting donated corneas for transplant surgery, Fan said.
"Chinese doctors can only perform corneal transplant operations, currently the only cure for corneal blindness, on 3,000 to 4,000 people every year due to a lack of donors," he said.
The cornea, a vulnerable shield protecting the eye and also playing a key role in creating vision, consists of three main layers - the endothelium, stroma and epithelium.
The research team had made a major breakthrough by using tissue-engineering technologies to create a tissue similar to the endothelium, an innermost, single layer of cells essential to keeping the cornea clear, Fan said.
The creation of endothelium remained a key barrier in the global study of artificial corneas because the cells of the endothelium could not regenerate, which added great difficulties to cell cultures, said Fan, whose team started their research in 2002.
Before 2002, many researchers throughout the world resorted to the cancer gene to stimulate the growth of endothelial cells during the culture.
"So their achievements couldn't apply to clinical therapies, but only for further research," Fan said.
After nine years of trial and error, the team successfully cultivated a large quantity of normal human endothelial cells with the assistance of supports made of human amnion.
China Daily
