The government in Japan says suicides and depression cost its economy almost 2.7tn yen ($32bn; £21bn) last year.
The figures refer to lost incomes and the cost of treatment. It is the first time Japan has released such figures.
Japan has one of the world's highest suicide rates, with more than 32,000 people killing themselves last year. PM Naoto Kan sees it as proof of an economic and emotional downturn.
The government is setting up a task force to try to reduce the rate.
From Friday, it will run a video clip of a footballer from the J-league on its website, urging people to be more aware of the problem.
BBC News